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Medeloop Analytics

From question to evidence. On any data.

AI research agents that work like an expert team — on your data, in your infrastructure. Federated execution means your data never leaves your walls.

Request a Demo Download third-party validation paper

Need data? EvidenceKit pairs the Analytics platform with all-payer claims data.

Research question
Pending
Evaluate feasibility
Pending
Research plan
Pending
Run analysis
Pending
How It Works

From question to evidence in five steps.

01

Ask

Submit your research question in plain English

02

Clarify

AI evaluates feasibility and clarifies study design

03

Plan

Protocol, cohort, and analysis plan — you review and edit

04

Execute

Validated code runs on your federated data

05

Deliver

Publication-ready outputs, figures, and audit trail

The Medeloop Flow

From question to a network of research outputs.

An agentic loop with human oversight at every step. Queries run on your data — and execute in your environment or ours, depending on your preference.

Your Data
Stays in your infra
EHR / EMR
Claims data
Registries
Labs
+ Custom sources
RESEARCH QUESTION

"What is the impact of Drug X on patients with Y?"

AGENTIC LOOP · DEPLOY ANYWHERE
01
Check feasibility
Assess data + study design
02
Draft study plan
Protocol + cohort design
Review + edit at any step Audit trail
03
Execute on your data
Runs in your environment — or Medeloop cloud
Deployment · You Choose
Your environment
Medeloop cloud
RESEARCH OUTPUTS
Publication
Impact of Drug X on Outcome Y
JAMA BMJ STROBE
Dashboard
Drug X
Standard care
Cohorts
102,813 patients
58.7
avg age
54%
female
All-payer
coverage
Platform Architecture

Compute goes to the data.
Your data never leaves.

Medeloop agents run inside your environment — your EHR system, your cloud, your data center. Zero data egress required.

YOUR INFRASTRUCTURE YOUR INFRASTRUCTURE COMPUTE COMPUTE COMPUTE COMPUTE EHR / EMR Epic · Cerner · Meditech Claims Data Commercial · Medicare · Medicaid Registries Disease · Specialty · OMOP Institutional Data I2B2 · Custom CDM · Research DATA STAYS HERE DATA STAYS HERE DATA STAYS HERE DATA STAYS HERE MEDELOOP Compute Layer

Six capabilities built into the platform.

01

Federated execution

Your data never leaves your infrastructure. Compute goes to the data.

02

Any data source

EHRs, claims, registries, institutional datasets. CDM-agnostic — OMOP, I2B2, or custom.

03

Model-agnostic

Works across OpenAI, Anthropic, DeepSeek. Best model for each task, not locked to one provider.

04

7-dimension validation

Continuous benchmarking — not a black box. Every output scored before delivery.

05

100K+ medical concept codes

ICD-10, CPT, NDC, SNOMED CT, NPI, LOINC, CCI, interRAI — every major coding system.

06

Protocol transparency

HARPER/STaRT-RWE standards. Every step auditable, reviewable, and export-ready.

Platform Capabilities

Built for real-world evidence — on any data, in any environment.

01

Federated by design

Compute goes to the data. Your data never leaves your infrastructure.

02

Data-agnostic architecture

Works on EHRs, claims, registries, or custom datasets. No CDM conversion required.

03

Semantic code engine

Maps research concepts to ICD-10, CPT, NDC, SNOMED, and every major coding system automatically.

04

Validated at every step

Built-in checks on code selection, statistical methodology, and output quality.

05

Human-in-the-loop reasoning

Editable research plans, full audit trails, and transparent agent actions.

06

Best model for every task

Uses the right AI model for each step — not locked to a single provider.

Platform Capabilities

Built for real-world evidence. From the ground up.

Six core capabilities that set Medeloop Analytics apart from every other tool in healthcare research.

Federated Execution

Your data never leaves your infrastructure.

Compute goes to the data. Medeloop agents run inside your environment — your EHR system, your cloud, your data center. Zero data egress required.

  • On-premise or VPC deployment
  • No data copying, no transfers, no egress costs
  • Compute runs in your secure environment
  • Compatible with all major cloud providers
Any Data Source

EHRs, claims, registries, institutional datasets.

Connect to any healthcare data source. CDM-agnostic — works with OMOP, I2B2, or your custom schema. No restructuring required.

  • Epic, Cerner, Meditech — native connectors
  • Claims: commercial, Medicaid, Medicare
  • OMOP, I2B2, and custom CDM support
  • Registries and specialty datasets
Model-Agnostic

Best model for each task. Not locked to one provider.

Medeloop routes tasks to the right AI model — OpenAI, Anthropic, or DeepSeek — based on what each step requires. You always get the best available capability.

  • Works across OpenAI, Anthropic, DeepSeek
  • Task-optimized model selection
  • Bring your own API keys or use ours
  • Air-gapped / on-premise model support
7-Dimension Validation

Continuous benchmarking — not a black box.

Every output is scored across seven quality dimensions before delivery. 82.6% overall quality score — validated against peer-reviewed published results.

  • 82.6% quality score across all output types
  • Reproducibility tested across repeated runs
  • Expert review concordance benchmarking
  • STROBE-aligned output formatting
100K+ Medical Concept Codes

Every coding system. Every terminology.

Medeloop's medical knowledge layer covers every major code system used in clinical research — from diagnosis codes to procedure codes to drug identifiers.

  • ICD-10-CM · CPT · NDC · SNOMED CT
  • NPI · LOINC · CCI · interRAI
  • Automatic code expansion and synonyms
  • Continually updated to current standards
Protocol Transparency

HARPER/STaRT-RWE standards. Every step auditable.

Full protocol documentation at every stage — from cohort definition to statistical model selection. Every decision is recorded, reviewable, and editable.

  • HARPER protocol template compliance
  • STaRT-RWE structured reporting
  • Full audit trail on every query
  • Export-ready research documentation
[ Screenshot: Federated Architecture Diagram ]
[ Screenshot: Data Source Connections ]
[ Screenshot: Model Selection UI ]
[ Screenshot: 7-Dimension Quality Score ]
[ Screenshot: Medical Code Browser ]
[ Screenshot: Protocol Audit Trail ]
What you can analyze

Real-world evidence, from any angle.

A sample of what researchers ask — and the answers they get back.

Full Research Landscape

Medeloop covers every major research category.

Clinical Outcomes & Safety

30-day readmissions In-hospital mortality Adverse events Joint replacement outcomes

Spending & Resource Use

Cost of hospital stay Health spending trends Pharmaceutical utilization Wait times

Population Health & Equity

Health equity stratification Avoidable deaths Patient-reported outcomes

Care Delivery & Workforce

LTC quality indicators Workforce metrics Continuing care performance
Trust & Credibility

Validated at every step —
from question to result.

We benchmark the pipeline at every checkpoint — from how we interpret your question to how we verify the final numbers. No black boxes.

01

Benchmarked by design

Every feature is validated against peer-reviewed research before it ships. We reproduce published results and compare outputs to ensure accuracy.

02

Validated on your data

Every dataset is different. Onboarding benchmarks validate the pipeline against your specific data structure and coding practices before you run a single query.

03

Fully auditable

Every query produces a complete audit trail — traceable, reviewable, reproducible. Every cohort definition and statistical choice is documented.

Validation Pipeline

Every stage is benchmarked against gold-standard references, published literature, and expert-curated annotations.

01
Query Understanding
"Did we interpret the intent correctly?"
02
Concept Extraction
"Did we identify the right clinical concepts?"
03
Code Mapping
"Did we pull the right ICD-10, CPT, NDC codes?"
04
Cohort Construction
"Did we build the right analytical cohort?"
05
Statistical Analysis
"Did we apply the right methodology?"
06
Result Verification
"Are the outputs accurate and reproducible?"
Download third-party validation paper
EvidenceKit · Analytics + Data

Don't have your own data?

Closed claims data published in JAMA, Science, and BMJ — paired with AI analytics in one subscription. Start publishing in minutes.

Closed claims · All-payer HIPAA Expert Determination Quarterly Refresh
Explore EvidenceKit →

No credit card. Free trial requires .edu email.

HIPAA Expert Determination certified
Research question
"What are the treatment patterns for newly diagnosed Type 2 Diabetes patients aged 40–65 with commercial insurance?"
Mapping cohort
Running analysis
Generating output
Results · 3 min 42 sec STROBE-aligned
Cohort size2.8M patients
First-line metformin67.3%
GLP-1 initiation18.9%
All-payer claims · Jan 2020–present
Use Cases

Built for every research team.

Health Systems

Analytics on your own data

Run analytics on your own EHR and claims data with AI agents. Identify care gaps, benchmark outcomes, and drive population health programs — accelerating work your team can build on.

Pharma & Life Sciences

National-scale RWE on demand

Connect proprietary datasets for validated real-world evidence. HEOR studies, treatment pattern analysis, and comparative effectiveness at national scale.

CROs

Multi-client studies, one platform

Multi-client data analytics on a single platform. Run studies across client datasets with full isolation, audit trails, and publication-ready outputs for every engagement.

Academic Medical Centers

From IRB to publication, faster

Faster research on IRB-approved institutional datasets. Ask a question in plain English, review the plan, and publish the results — augmenting the work your research team already does.

Frequently asked questions

Does my data ever leave my infrastructure?

Never. Medeloop uses a federated execution model — the compute goes to your data, not the other way around. Your data stays in your infrastructure, and only aggregated, de-identified results are returned. No raw patient data ever leaves your walls.

Can I choose where Medeloop runs — my environment or yours?

Yes. Medeloop deploys in your environment (AWS, Azure, GCP, or on-prem) or in the Medeloop cloud — you pick based on your compliance, security, and operational preferences. In either configuration, queries run on your data and only results are returned.

What data sources does Medeloop Analytics support?

Medeloop works with EHRs, claims datasets, disease registries, labs, and institutional databases — including custom schemas. If you have structured clinical data, Medeloop can run on it.

Do I need to convert my data to OMOP or another common data model?

No. Our semantic engine reads your data natively — no OMOP mapping, no CDM conversion, no months of prep. If you already have OMOP, I2B2, or another common data model in place, Medeloop works with those too.

Do I need to know SQL, R, or Python to use it?

No coding required to get started. You describe your research question in plain English and the agentic pipeline handles cohort definition, query execution, statistical analysis, and output generation. For technical teams, every step is fully inspectable — with editable code, full audit trails, and the ability to drop into Python for deeper customization.

How do you validate outputs?

Every stage of the pipeline is benchmarked against gold-standard references, published literature, and expert-curated annotations. We validate six checkpoints — query understanding, concept extraction, code mapping, cohort construction, statistical analysis, and result verification. A third-party validation paper is available on request.

What outputs does a completed study produce?

Each study produces a defined patient cohort, the full query execution log, statistical outputs (Kaplan-Meier curves, regression tables, descriptive statistics), data visualizations, and a manuscript-ready narrative report. Every output is traceable, reviewable, and reproducible — designed to hold up to peer review, IRB review, or board presentation.

How long does it take to run a study?

Most analyses complete in minutes. Complex multi-step studies with large cohorts may take longer depending on your data infrastructure. The agentic pipeline runs all steps automatically — you review the plan, approve it, and the system handles execution.

Is Medeloop Analytics the same as EvidenceKit?

Analytics is the platform — it runs on your own data. EvidenceKit pairs the Analytics platform with the licensed HealthVerity all-payer claims dataset in a single subscription. If you don't have your own institutional data yet, EvidenceKit is the fastest way to start.

Medeloop Analytics

See what your data can reveal.

Real-world evidence at the speed of a question.

Request a Demo